Genetic disorders can have a huge impact on every aspect of our health,
including fertility. Since it’s hard to treat an illness that is written
into your DNA, it can be difficult to overcome these conditions. Let’s
take a look at how genes can affect fertility in both women and men.
Genetic Causes of Male Infertility
Genetic disorders in men affect the production of sperm and sexual development in general. For example:- Kallman syndrome also affects men and results in low levels of testosterone, LH, and FSH, the hormones responsible for fertility. Almost all men with Kallman syndrome also experience decreased libido and erectile dysfunction.
- Y chromosome microdeletion is a genetic disorder that can result in low sperm count, no sperm production, or abnormal sperm morphology and motility. Some men with this disorder may have small or undescended testes.
- Men with Klinefelter syndrome have smaller testes than average and produce less testosterone than normal. This leads to delayed or incomplete puberty, infertility, and other physical symptoms.
- Hormone replacement can treat the decreased libido and erectile dysfunction of Kallman syndrome, as well as potentially stimulate fertility.
- In about two-thirds of cases of Y chromosome microdeletion, some sperm can be extracted from the testes and used in assisted reproduction. Sperm production in these cases may also respond to the natural lifestyle changes often suggested for men without the condition.
- While testosterone treatments can help with many of the physical effects of Klinefelter syndrome, it typically won’t improve fertility. Some men with the condition may have minimal sperm production, in which case sperm may be extracted for use in other procedures.
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